Cubs vs. Reds Prediction, Odds, Picks – August 6 Updated Aug. 6, 2025 2:00 p.m. ET sharefacebookxredditlink Data Skrive Nico Hoerner and the Chicago Cubs will square off against Elly De La Cruz and the Cincinnati Reds at Wrigley Field on Wednesday. The favored Cubs have -186 moneyline odds against the underdog Reds, who are listed at +154. Chicago (-1.5) is the favorite on the run line. The total is 7.5 runs for this game. Here is everything you need from a betting perspective on the Cubs-Reds game, regarding the run line, moneyline and total, plus expert picks.Keep up with MLB on FOX Sports.Reds vs. Cubs Highlights | MLB on FOX Check out the best moments from this MLB matchup between the Cincinnati Reds and the Chicago Cubs. ADVERTISEMENT Cubs vs. Reds Game Information & OddsWhen: Wednesday, August 6, 2025 at 2:20 p.m. ETWhere: Wrigley Field in Chicago, IllinoisHow to watch on TV: MARQ and FDSOH Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Cubs -186 +154 7.5 +103 -124 -1.5 +119 -142 Cubs vs. Reds PredictionScore Prediction: Cubs 4, Reds 3Total Prediction: Over 7.5 runsWin Probabilities: Cubs 56%, Reds 44%Cubs vs. Reds Betting InsightsThis season, the Cubs have been favored 79 times and won 52, or 65.8%, of those games.Chicago is 15-4 this season when entering a game favored by -186 or more on the moneyline.The moneyline for this contest implies a 65% chance of a victory for the Cubs.The Reds have come away with 32 wins in the 60 contests they have been listed as the underdogs in this season.Cincinnati has a mark of 3-7 in contests where bookmakers favor it by +154 or worse on the moneyline.The moneyline set for this matchup implies the Reds have a 39.4% chance of walking away with the win.Cubs Recent Betting PerformanceThe Cubs went 4-4 over the eight games they were a moneyline favorite in their last 10 matchups.Over their last 10 outings (all 10 of them had set totals), the Cubs and their opponents combined to go over the run total four times.The Cubs’ ATS record is 3-7-0 over their past 10 games. Cubs Recent Stats Stat Avg/Total Record 5-5 Runs Per Game 4 HR 8 ERA 3.89 K/9 8 Cubs Player InsightsKyle Tucker is hitting .271 with 21 doubles, four triples, 18 home runs and 75 walks.In all of Major League Baseball, Tucker is 48th in homers and 45th in RBI.Pete Crow-Armstrong has put his power on display as he leads his team with 27 home runs.Crow-Armstrong is seventh in home runs in the majors, and ninth in RBI.Seiya Suzuki has a team-high 82 runs batted in.Hoerner has a club-leading .290 batting average.Cubs Team Props Hits O/U Total Bases O/U HR O/U RBI O/U Seiya Suzuki 0.5 (-200) 1.5 (+135) – 0.5 (+190) Carson Kelly 0.5 (-210) 1.5 (+135) – 0.5 (+180) Nico Hoerner 1.5 (+195) 1.5 (+120) – 0.5 (+220) Kyle Tucker – – – – Cade Horton – – – – Reds Recent Betting PerformanceThe Reds have played as underdogs in five of their past 10 games and have gone 3-2 in those contests.In their last 10 games with a total, the Reds and their opponents have failed to hit the over nine times.The Reds are 7-3-0 ATS over their last 10 games. Reds Recent Stats Stat Avg/Total Record 6-4 Runs Per Game 4.3 HR 8 ERA 3.36 K/9 10.2 Reds Player InsightsDe La Cruz leads the Reds in home runs (19), runs batted in (73) and has put up a team-best batting average of .279.De La Cruz’s home run total puts him 38th in MLB, and he is 14th in RBI.TJ Friedl is batting .273 with 16 doubles, two triples, 10 home runs and 54 walks.Among all major league hitters, Friedl ranks 147th in home runs and 169th in RBI.Spencer Steer is hitting .239 with 15 doubles, two triples, 13 home runs and 32 walks.Matt McLain has 12 doubles, 11 home runs and 41 walks while hitting .223.Reds Team Props Hits O/U Total Bases O/U HR O/U RBI O/U Elly De La Cruz 0.5 (-215) 1.5 (+130) – 0.5 (+210) Matt McLain – – – – Andrew Abbott – – – – Tyler Stephenson 0.5 (-140) – – 0.5 (+220) TJ Friedl 0.5 (-190) – – 0.5 (+260) Reds vs. Cubs Highlights | MLB on FOX Check out the best moments from this MLB matchup between the Cincinnati Reds and the Chicago Cubs. FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily. FOLLOW Follow your favorites to personalize your FOX Sports experience Chicago Cubs Cincinnati Reds What did you think of this story?